Technology Process of Z-Ala-Gly-Cys(MBzl)-Lys(Z)-Asn-Phe-Phe-NHNH-Boc
There total 11 articles about Z-Ala-Gly-Cys(MBzl)-Lys(Z)-Asn-Phe-Phe-NHNH-Boc which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DCC / ethyl acetate / 2.17 h / 0 °C
2: sodium hydrogen carbonate / H2O; tetrahydrofuran / 0.08 h
3: DCC / ethyl acetate / 4 h / 0 °C
4: triethylamine / ethyl acetate / 0.08 h
5: 87.5 percent / hydrazyne hydrate / methanol / 48 h / Ambient temperature
6: 1) 2.2N hydrogen chloride, tert-butyl nitrite 2) triethylamine / 1) -30deg C, DMF, 20 min 2) 0 deg C, DMF, 2 days
With
hydrogenchloride; tert.-butylnitrite; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DCC / ethyl acetate / 0 °C
2: 80 percent / CHCl3 / 0.17 h
3: hydrogen / methanol / 3 h
4: tetrahydrofuran / 0.5 h
5: hydrogen / dimethylformamide / 1 h / Ambient temperature
6: 1) 2.2N hydrogen chloride, tert-butyl nitrite 2) triethylamine / 1) -30deg C, DMF, 20 min 2) 0 deg C, DMF, 2 days
With
hydrogenchloride; tert.-butylnitrite; hydrogen; triethylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DCC / ethyl acetate / 4 h / 0 °C
2: triethylamine / ethyl acetate / 0.08 h
3: 87.5 percent / hydrazyne hydrate / methanol / 48 h / Ambient temperature
4: 1) 2.2N hydrogen chloride, tert-butyl nitrite 2) triethylamine / 1) -30deg C, DMF, 20 min 2) 0 deg C, DMF, 2 days
With
hydrogenchloride; tert.-butylnitrite; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide;
In
methanol; ethyl acetate;
