4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

Base Information

Chemical Name:4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide
CAS No.:1396721-60-0
Molecular Formula:C₂₆H₂₃ClN₄O
Molecular Weight:442.948
Hs Code.:

Synonyms:4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

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Chemical Property of 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

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Technology Process of 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

There total 8 articles about 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396723-11-7
tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

: 1396721-60-0
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

: 56525-63-4
methyl 3-chloro-4-methyl-benzoate

: 1396721-60-0
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2.1: toluene / 6 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

3.2: 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

5.2: 50 °C

6.1: potassium hydroxide; water / methanol / 20 °C

6.2: pH 5

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1396722-97-6
tert-butyl 3-(2-chloro-4-(methoxycarbonyl)benzylidene)azetidine-1-carboxylate

: 1396721-60-0
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-N-(2-aminophenyl)-3-chlorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

2.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

2.2: 50 °C

3.1: potassium hydroxide; water / methanol / 20 °C

3.2: pH 5

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;