tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate
CAS No.:1396723-11-7
Molecular Formula:C₃₁H₃₁ClN₄O₃
Molecular Weight:543.065
Hs Code.:

Synonyms:tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

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Chemical Property of tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

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Technology Process of tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

There total 7 articles about tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396723-08-2
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

: 146651-75-4
tert–butyl (2–aminophenyl)carbamate

: 1396723-11-7
tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 56525-63-4
methyl 3-chloro-4-methyl-benzoate

: 1396723-11-7
tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2.1: toluene / 6 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

3.2: 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

5.2: 50 °C

6.1: potassium hydroxide; water / methanol / 20 °C

6.2: pH 5

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;

Reference yield:

: 74733-30-5
methyl 4-Bromomethyl-3-chlorobenzoate

: 1396723-11-7
tert-butyl (2-(4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzamido)phenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 6 h / 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

2.2: 65 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

4.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

4.2: 50 °C

5.1: potassium hydroxide; water / methanol / 20 °C

5.2: pH 5

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;