3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

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Chemical Name:3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide
CAS No.:1625677-42-0
Molecular Formula:C₃₀H₃₆N₈O₃
Molecular Weight:556.668
Hs Code.:

Synonyms:3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

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Chemical Property of 3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

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Technology Process of 3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

There total 9 articles about 3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1671094-97-5
3-chloro-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

: 124-40-3
dimethyl amine

: 1625677-42-0
3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

Guidance literature:: In tetrahydrofuran; at 20 - 50 ℃; for 73.5h;

Reference yield:

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1625677-42-0
3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.17 h / -78 °C

1.2: 3.17 h / -78 - 20 °C

2.1: peracetic acid / dichloromethane; acetic acid / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: tetrahydrofuran / 73.5 h / 20 - 50 °C

With peracetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; acetic acid; tert-butyl alcohol;

Reference yield:

: 1584151-29-0
tert-butyl (3-(2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate

: 1625677-42-0
3-(dimethylamino)-N-(3-(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: peracetic acid / dichloromethane; acetic acid / 0 °C

2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 21 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5: tetrahydrofuran / 73.5 h / 20 - 50 °C

With peracetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; tert-butyl alcohol;