2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

Base Information

Chemical Name:2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide
CAS No.:1299492-08-2
Molecular Formula:C₁₉H₂₃N₃O₃
Molecular Weight:341.41
Hs Code.:

Synonyms:2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

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Chemical Property of 2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

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Technology Process of 2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

There total 4 articles about 2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1299492-07-1
2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

: 1299492-08-2
2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

Guidance literature:: 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide; With sulfuric acid; In dichloromethane; water; at -10 - 0 ℃; for 3.25h; Cooling with ice;

With ammonia; In dichloromethane; water; pH=8 - 9; Product distribution / selectivity;

Reference yield:

: 700-63-0,6485-52-5,6485-67-2,58429-87-1
(R)-phenylglycine amide

: 1299492-08-2
2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol

2.1: water; methanol / 20 h / 40 °C / Sealed tube

3.1: sulfuric acid / dichloromethane; water / 3.25 h / -10 - 0 °C / Cooling with ice

3.2: pH 8 - 9

With hydrogenchloride; sulfuric acid; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 1299492-08-2
2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; methanol / 20 h / 40 °C / Sealed tube

2.1: sulfuric acid / dichloromethane; water / 3.25 h / -10 - 0 °C / Cooling with ice

2.2: pH 8 - 9

With sulfuric acid; In methanol; dichloromethane; water;