2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

Base Information

Chemical Name:2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide
CAS No.:1299492-07-1
Molecular Formula:C₁₉H₂₁N₃O₂
Molecular Weight:323.395
Hs Code.:

Synonyms:2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

Suppliers and Price of 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

Chemical Property:

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Technology Process of 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

There total 2 articles about 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 773837-37-9
sodium cyanide

: 122-84-9
4-methoxybenzyl methyl ketone

: 63291-39-4
(R)-phenylglycine amide hydrochloride

: 1299492-07-1
2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

Guidance literature:: In methanol; water; at 40 ℃; for 20h; Product distribution / selectivity; Sealed tube;

Reference yield:

: 700-63-0,6485-52-5,6485-67-2,58429-87-1
(R)-phenylglycine amide

: 1299492-07-1
2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; methanol

2: water; methanol / 20 h / 40 °C / Sealed tube

With hydrogenchloride; In 1,4-dioxane; methanol; water;

Reference yield: 94.0%

: 1299492-07-1
2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide

: 1299492-08-2
2-[(R)-(carbamoylphenylmethyl)-amino]-3-(4-methoxyphenyl)-2-(S)-methylpropionamide

Guidance literature:: 2-[1-(S)-cyano-2-(4-methoxyphenyl)-1-methylethylamino]-2-(R)-phenylacetamide; With sulfuric acid; In dichloromethane; water; at -10 - 0 ℃; for 3.25h; Cooling with ice;

With ammonia; In dichloromethane; water; pH=8 - 9; Product distribution / selectivity;