4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide

Base Information

• Chemical Name: 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide
• CAS No.: 718638-37-0
• Molecular Formula: C₁₄H₁₇NO₄S
• Molecular Weight: 295.359
• Mol file: 718638-37-0.mol

Synonyms:4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide

Chemical Property of 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide

There total 1 articles about 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5) + 4-but-2-ynyloxybenzenesulfonyl chloride (286459-94-7) → 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide (718638-37-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield:

4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide (718638-37-0) → 4-but-2-ynyloxy-N-[(S)-3-mercaptopyrrolidinyl]benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P; DEAD / tetrahydrofuran

2: aq. sodium methoxide / methanol

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2007.01.064

Reference yield:

4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide (718638-37-0) + tiolacetic acid (507-09-5) → C16H19NO4S2 (718638-38-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.01.064

upstream raw materials:

(3R)-pyrrolidinol

4-but-2-ynyloxybenzenesulfonyl chloride

Downstream raw materials:

C₁₆H₁₉NO₄S₂