1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

Base Information

Chemical Name:1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine
CAS No.:1449038-90-7
Molecular Formula:C₂₂H₂₁ClN₄
Molecular Weight:376.889
Hs Code.:

Synonyms:1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

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Technology Process of 1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

There total 2 articles about 1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 92-54-6
4-phenyl-1-piperazine

: 1449038-89-4
1-(4-chlorophenyl)-4-iodo-1H-pyrazole

: 106-96-7
propargyl bromide

: 1449038-90-7
1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 0 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.027

Reference yield:

: 25419-86-7
1-(4-chlorophenyl)-1H-pyrazole

: 1449038-90-7
1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; iodine / water; acetonitrile / 24 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 20 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dihydrogen peroxide; iodine; In water; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2013.05.027