Technology Process of 10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione
There total 7 articles about 10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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1278416-40-2
10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione
- Guidance literature:
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methyl [(4Z)-4-(4-benzyl-1,4-diazepan-2-ylidene)-1-(2-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate;
With
sodium methylate;
In
isopropyl alcohol;
at 20 ℃;
for 0.5h;
Inert atmosphere;
With
hydrogenchloride;
In
water; isopropyl alcohol;
pH=6;
Cooling;
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1278416-40-2
10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 130 - 140 °C
2.1: N-ethyl-N,N-diisopropylamine / toluene / 46 h / 140 °C
3.1: acetic acid / acetonitrile / 70 °C / Inert atmosphere
4.1: acetonitrile / 0.5 h / 0 °C
5.1: sodium methylate / isopropyl alcohol / 0.5 h / 20 °C / Inert atmosphere
5.2: pH 6 / Cooling
With
sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
isopropyl alcohol; toluene; acetonitrile;
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1278416-40-2
10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 130 - 140 °C
2.1: N-ethyl-N,N-diisopropylamine / toluene / 46 h / 140 °C
3.1: acetic acid / acetonitrile / 70 °C / Inert atmosphere
4.1: acetonitrile / 0.5 h / 0 °C
5.1: sodium methylate / isopropyl alcohol / 0.5 h / 20 °C / Inert atmosphere
5.2: pH 6 / Cooling
With
sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
isopropyl alcohol; toluene; acetonitrile;