methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Base Information

• Chemical Name: methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate
• CAS No.: 1158233-60-3
• Molecular Formula: C₁₂H₁₁ClN₂O₃
• Molecular Weight: 266.684
• Mol file: 1158233-60-3.mol

Synonyms:methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Chemical Property of methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

Chemical Property:

• Boiling Point: 426.9±40.0 °C(Predicted)
• PKA: 7.68±0.50(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

There total 4 articles about methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) + (2-chlorophenyl)hydrazine (10449-07-7) → methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1158233-60-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 130 - 140 ℃; for 48h;

Reference yield:

C13H15ClN2O4 → methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1158233-60-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 140 ℃; for 46h;

Reference yield:

(2-chlorophenyl)hydrazine (10449-07-7) → methyl [1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate (1158233-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 130 - 140 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 46 h / 140 °C

With N-ethyl-N,N-diisopropylamine; In toluene;

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

(2-chlorophenyl)hydrazine

Downstream raw materials:

methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl]acetate

methyl [(4Z)-4-(4-benzyl-1,4-diazepan-2-ylidene)-1-(2-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]acetate

10-benzyl-2-(2-chlorophenyl)-2,3,8, 9,10,11-hexahydro-1H-pyrazolo[4',3':3,4]pyrido[1,2-a][1,4]diazepine-1,5(7H)-dione

methyl [4-(chloroacetyl)-1-(2-chlorophenyl)-5-hydroxy-1H-pyrazol-3-yl] acetate