methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Name:methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610369-72-6
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Chemical Property of methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

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Technology Process of methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 5 articles about methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 67-56-1
methanol

: 1610369-71-5
5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-72-6
methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: methanol; 5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide; With hydrogenchloride; In acetic acid methyl ester; at 20 - 40 ℃; for 168h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; pH=Ca. 2;

Reference yield:

: 1610369-70-4
ethyl 5-(cyanomethyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-72-6
methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

2.1: hydrogenchloride / acetic acid methyl ester / 168 h / 20 - 40 °C / Inert atmosphere

2.2: pH Ca_. 2

With hydrogenchloride; potassium cyanide; In methanesulfonic acid; acetic acid methyl ester;

Reference yield:

: 1610369-69-1
ethyl 5-(cyanomethyl)-1-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-72-6
methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

2.1: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

3.1: hydrogenchloride / acetic acid methyl ester / 168 h / 20 - 40 °C / Inert atmosphere

3.2: pH Ca_. 2

With hydrogenchloride; potassium cyanide; oxygen; copper diacetate; triethylamine; In methanesulfonic acid; dichloromethane; acetic acid methyl ester;