5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide
CAS No.:1610369-71-5
Molecular Formula:C₂₁H₂₂N₄O₂
Molecular Weight:362.431
Hs Code.:

Synonyms:5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

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Technology Process of 5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

There total 4 articles about 5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1610369-70-4
ethyl 5-(cyanomethyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 124-40-3
dimethyl amine

: 1610369-71-5
5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

Guidance literature:: With potassium cyanide; In methanesulfonic acid; at 45 ℃; Sealed tube;

Reference yield:

: 1610369-69-1
ethyl 5-(cyanomethyl)-1-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-71-5
5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

2: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

With potassium cyanide; oxygen; copper diacetate; triethylamine; In methanesulfonic acid; dichloromethane;

Reference yield:

: 27143-07-3
ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

: 1610369-71-5
5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: silver(I) acetate / toluene / 20 °C / Inert atmosphere

2: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

3: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

4: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

With potassium cyanide; boron dimethyl-trifluoro sulphide; oxygen; silver(I) acetate; copper diacetate; triethylamine; In methanesulfonic acid; dichloromethane; toluene;