2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Base Information

Chemical Name:2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid
CAS No.:1610369-67-9
Molecular Formula:C₂₁H₂₃N₃O₄
Molecular Weight:381.431
Hs Code.:

Synonyms:2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Chemical Property of 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

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Technology Process of 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

There total 6 articles about 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1610369-72-6
methyl 2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

: 1610369-67-9
2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1610369-68-0
ethyl 5-(cyanomethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate

: 1610369-67-9
2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron dimethyl-trifluoro sulphide / dichloromethane / 6 h / 0 - 20 °C

2.1: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

3.1: potassium cyanide / methanesulfonic acid / 45 °C / Sealed tube

4.1: hydrogenchloride / acetic acid methyl ester / 168 h / 20 - 40 °C / Inert atmosphere

4.2: pH Ca_. 2

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; potassium cyanide; boron dimethyl-trifluoro sulphide; water; oxygen; copper diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanesulfonic acid; dichloromethane; acetic acid methyl ester;

Reference yield:

: 1610369-71-5
5-(cyanomethyl)-N,N-dimethyl-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-67-9
2-(3-(dimethylcarbamoyl)-1-(4-(o-tolyloxy)phenyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / acetic acid methyl ester / 168 h / 20 - 40 °C / Inert atmosphere

1.2: pH Ca_. 2

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; water; lithium hydroxide; In tetrahydrofuran; acetic acid methyl ester;