(3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate

Base Information

Chemical Name:(3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate
CAS No.:552302-70-2
Molecular Formula:C₄₀H₆₄O₃Si
Molecular Weight:621.032
Hs Code.:
Mol file:552302-70-2.mol

Synonyms:(20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol benzoate

Suppliers and Price of (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol3-Benzoate
1 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate

Chemical Property:

Purity/Quality:: (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol3-Benzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate is used in the preparation of follicular fluid-meiosis activating sterols (FF-MAS).

Technology Process of (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate

There total 5 articles about (3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 462102-91-6
(20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol

: 552302-70-2
(20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol benzoate

Guidance literature:: With pyridine; at 0 ℃; for 1h;
DOI:10.1021/ol0343156

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 552302-70-2
(20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / CH₂Cl₂ / 4 h / 20 °C

2: t-BuOK / 2-methyl-propan-2-ol / 0.5 h / 20 °C

3: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4: pyridine / 1 h / 0 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol0343156

Reference yield:

: 40736-33-2
(20S)-20-hydroxymethylpregn-4-en-3-one

: 552302-70-2
(20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / CH₂Cl₂ / 4 h / 20 °C

2: t-BuOK / 2-methyl-propan-2-ol / 0.5 h / 20 °C

3: LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4: pyridine / 1 h / 0 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol0343156