Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Base Information

Chemical Name:Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate
CAS No.:134373-07-2
Molecular Formula:C₂₄H₃₀N₆O₅
Molecular Weight:482.539
Hs Code.:

Synonyms:Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Chemical Property of Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Technology Process of Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

There total 4 articles about Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 16450-41-2
L-glutamic acid diethyl ester

: 149010-53-7
4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

: 134373-07-2
Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In N,N-dimethyl-formamide; 1.) 25 deg C, 1.5 h, 2.) 25 deg C, 4 h;
DOI:10.1021/jo00126a017

Reference yield:

: 151864-73-2
Ethyl 4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoate

: 134373-07-2
Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 0.5 N NaOH / methanol / 15 h / Heating

2: 62 percent / NMM, 2-chloro-4,6-dimethoxy-1,3,5-triazine / dimethylformamide / 1.) 25 deg C, 1.5 h, 2.) 25 deg C, 4 h

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00126a017

Reference yield:

: 134373-01-6
4-(4,4-Dicyano-3-dimethoxymethyl-butyl)-benzoic acid tert-butyl ester

: 134373-07-2
Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / 1 M t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / Heating

2: CF₃COOH, H₂O

3: diethyl phoshorocyanidate, triethylamine / dimethylformamide

With diethyl cyanophosphonate; potassium tert-butylate; water; triethylamine; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo00059a016