methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide

Base Information

• Chemical Name: methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide
• CAS No.: 247088-31-9
• Molecular Formula: C₂₀H₂₀N₂OS₂
• Molecular Weight: 368.524
• Mol file: 247088-31-9.mol

Synonyms:methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide

Chemical Property of methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide

There total 3 articles about methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methylthio-1-propanamine (4104-45-4) + methyl 4-[(4-phenyl)thiazol-2-yl]benzoate (247088-29-5) → methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide (247088-31-9)

Guidance literature:

at 70 - 75 ℃;

DOI:10.1016/S0968-0896(99)00092-9

Reference yield:

4-cyanobenzoic acid methyl ester (1129-35-7) → methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide (247088-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / H₂S; diethylamine / dimethylformamide / 1 h / 60 - 65 °C

2: 97 percent / dimethylformamide / 2 h / 60 - 65 °C

3: 98 percent / 70 - 75 °C

With hydrogen sulfide; diethylamine; In N,N-dimethyl-formamide; 1: Addition / 2: Cyclization / 3: aminolysis;

DOI:10.1016/S0968-0896(99)00092-9

Reference yield:

methyl 4-(aminothioxomethyl)benzoate (80393-38-0) → methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide (247088-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / dimethylformamide / 2 h / 60 - 65 °C

2: 98 percent / 70 - 75 °C

In N,N-dimethyl-formamide; 1: Cyclization / 2: aminolysis;

DOI:10.1016/S0968-0896(99)00092-9

upstream raw materials:

3-methylthio-1-propanamine

methyl 4-[(4-phenyl)thiazol-2-yl]benzoate

4-cyanobenzoic acid methyl ester

methyl 4-(aminothioxomethyl)benzoate