(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester

Base Information

Chemical Name:(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester
CAS No.:328086-57-3
Molecular Formula:C14H22N2O6
Molecular Weight:314.33400
Hs Code.:
Mol file:328086-57-3.mol

Synonyms:(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanomethyl)-L-glutamic Acid 1,5-Dimethyl Ester;

Suppliers and Price of (4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanomethyl)-L-glutamicAcid1,5-DimethylEster
500mg
$ 1230.00

Medical Isotopes, Inc.
(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanomethyl)-L-glutamicAcid1,5-DimethylEster
500 mg
$ 2120.00

Medical Isotopes, Inc.
(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanomethyl)-L-glutamicAcid1,5-DimethylEster
50 mg
$ 640.00

ChemScene
Dimethyl(2S,4R)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate
1g
$ 450.00

ChemScene
Dimethyl(2S,4R)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate
250mg
$ 225.00

ChemScene
Dimethyl(2S,4R)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate
100mg
$ 135.00

AK Scientific
Dimethyl(2R,4S)-2-(cyanomethyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
1g
$ 998.00

Total 15 raw suppliers

Chemical Property of (4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester

Chemical Property:

Boiling Point:460.6±45.0 °C(Predicted)
PKA:10.88±0.46(Predicted)
PSA：114.72000
Density:1.151±0.06 g/cm3(Predicted)
LogP:1.53658
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(4R)-N-(tert-Butyloxycarbonyl)-4-(cyanomethyl)-L-glutamicAcid1,5-DimethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester is the l-Glutamic Acid (G596960) derivative,used in the preparation of protease inhibitors.

Technology Process of (4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester

There total 6 articles about (4R)-N-(tert-Butyloxycarbonyl)-4-(cyanoMethyl)-L-glutaMic Acid 1,5-DiMethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 590-17-0
cyanomethyl bromide

: 328086-57-3
(2S,4S)-2-tert-butoxycarbonylamino-4-cyanomethyl-pentadioic acid dimethyl ester

Guidance literature:: dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

cyanomethyl bromide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(01)01416-2

Reference yield: 72.0%

: 624-75-9
iodoacetonitrile

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 328086-57-3
(2S,4S)-2-tert-butoxycarbonylamino-4-cyanomethyl-pentadioic acid dimethyl ester

Guidance literature:: dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

iodoacetonitrile; In tetrahydrofuran; at -78 - -70 ℃; for 3h; stereoselective reaction; Inert atmosphere;
DOI:10.1007/s11426-011-4478-5

Reference yield:

: 590-17-0
cyanomethyl bromide

: 328086-57-3
(2S,4S)-2-tert-butoxycarbonylamino-4-cyanomethyl-pentadioic acid dimethyl ester

Guidance literature:: dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

cyanomethyl bromide; In tetrahydrofuran; at -78 - -70 ℃; for 2 - 3h;

With methanol; acetic acid; more than 3 stages;