Technology Process of allyl 2-O-benzyl-3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-α-D-glycopyranoside
There total 13 articles about allyl 2-O-benzyl-3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-α-D-glycopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid;
In
water;
at 50 ℃;
for 4h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium methylate / methanol / 3 h / 20 °C
1.2: 0.5 h / 0 °C
1.3: 20 °C
2.1: sodium hydrogencarbonate; Oxone / dichloromethane; water; acetone / 2 h
2.2: 20 °C
3.1: dmap / dichloromethane / 18 h / 20 °C
4.1: hydrogen / (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate / tetrahydrofuran / Inert atmosphere
4.2: 2 h
5.1: potassium carbonate / dichloromethane / 8 h / 20 °C
6.1: dichloromethane / 0.17 h / AW-300 molecular sieves
6.2: 0.5 h / 0 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
7.2: 18 h / 20 °C
8.1: acetic acid / water / 4 h / 50 °C
With
dmap; Oxone; hydrogen; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid;
(1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium methylate / methanol / 3 h / 20 °C
1.2: 0.5 h / 0 °C
1.3: 20 °C
2.1: sodium hydrogencarbonate; Oxone / dichloromethane; water; acetone / 2 h
2.2: 20 °C
3.1: dmap / dichloromethane / 18 h / 20 °C
4.1: hydrogen / (1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate / tetrahydrofuran / Inert atmosphere
4.2: 2 h
5.1: potassium carbonate / dichloromethane / 8 h / 20 °C
6.1: dichloromethane / 0.17 h / AW-300 molecular sieves
6.2: 0.5 h / 0 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
7.2: 18 h / 20 °C
8.1: acetic acid / water / 4 h / 50 °C
With
dmap; Oxone; hydrogen; sodium methylate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid;
(1,5-cyclooctadiene)[bis(methyldiphenylphosphine)]iridium(I) hexafluorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
