dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

Base Information

Chemical Name:dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate
CAS No.:1271521-34-6
Molecular Formula:C₂₂H₂₉N₃O₈S
Molecular Weight:495.554
Hs Code.:

Synonyms:dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

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Chemical Property of dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

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Technology Process of dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

There total 9 articles about dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1271521-33-5
dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-[(4-but-2-ynyloxybenzoylamino)methyl]malonate

: 124-63-0
methanesulfonyl chloride

: 1271521-34-6
dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1271521-34-6
dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / butanone / 23 h / 20 °C / Reflux

2.1: sodium hydroxide; water / tetrahydrofuran / 23 h / 45 °C / Reflux

2.2: pH 6

3.1: N-cyclohexyl-cyclohexanamine / dichloromethane / 0.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 3 h / 20 °C

With water; potassium carbonate; triethylamine; N-cyclohexyl-cyclohexanamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; butanone;

Reference yield:

: 868-26-8
dimethyl 2-bromomalonate

: 1271521-34-6
dimethyl 2-[(4-but-2-ynyloxybenzoylamino)methyl]-2-(4-methanesulphonylpiperazin-1-yl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 24 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 2 - 20 °C

2.2: 20 h / 2 - 20 °C

3.1: hydrazine hydrate / methanol / 3 h / -5 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 3 h / 20 °C

With hydrazine hydrate; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;