benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

Base Information

Chemical Name:benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide
CAS No.:334708-38-2
Molecular Formula:C₂₆H₂₆O₃S
Molecular Weight:418.557
Hs Code.:

Synonyms:benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

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Chemical Property of benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

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Technology Process of benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

There total 5 articles about benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 215715-43-8
β,β-dibromo-3-isopropoxy-4-methoxystyrene

: 334708-19-9
benzyl 2-iodo-5-methoxyphenyl sulfide

: 334708-38-2
benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

Guidance literature:: β,β-dibromo-3-isopropoxy-4-methoxystyrene; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 0.33h;

benzyl 2-iodo-5-methoxyphenyl sulfide; With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ol0067179

Reference yield:

: 153898-63-6
2-iodo-5-methoxyaniline

: 334708-38-2
benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / HBF₄; NaNO₂ / H₂O / 0.5 h / 0 - 20 °C

2.1: acetone / 1.75 h / 0 - 20 °C

3.1: KOH / methanol / 3 h

4.1: 59 percent / n-Bu₄NHSO₄ / CH₂Cl₂; H₂O / 1 h

5.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.33 h / -78 - 20 °C

5.2: 96 percent / ZnCl₂; Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 1 h / 20 °C

With potassium hydroxide; tetrafluoroboric acid; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/ol0067179

Reference yield:

: 874903-81-8
dithiocarbonic acid O-ethyl ester S-(2-iodo-5-methoxyphenyl)

: 334708-38-2
benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide

Guidance literature:: Multi-step reaction with 3 steps

1.1: KOH / methanol / 3 h

2.1: 59 percent / n-Bu₄NHSO₄ / CH₂Cl₂; H₂O / 1 h

3.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.33 h / -78 - 20 °C

3.2: 96 percent / ZnCl₂; Pd(PPh₃)2Cl₂ / tetrahydrofuran; various solvent(s) / 1 h / 20 °C

With potassium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol0067179