2-(α-styryl)benzaldehyde

Base Information

• Chemical Name: 2-(α-styryl)benzaldehyde
• CAS No.: 871563-46-1
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• Mol file: 871563-46-1.mol

Synonyms:2-(α-styryl)benzaldehyde

Chemical Property of 2-(α-styryl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(α-styryl)benzaldehyde

There total 11 articles about 2-(α-styryl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromovinylbenzene (98-81-7) + 2-formylbenzene boronic acid (40138-16-7) → 2-(α-styryl)benzaldehyde (871563-46-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1002/anie.201709375

Reference yield: 83.0%

N-Formylpiperidine (2591-86-8) + 1-bromo-2-(1-phenylpropen-1-yl)benzene (24892-82-8) → 2-(α-styryl)benzaldehyde (871563-46-1)

Guidance literature:

1-bromo-2-(1-phenylpropen-1-yl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

N-Formylpiperidine; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.3987/COM-17-13803

Reference yield: 49.0%

phenylvinylboronic acid (14900-39-1) + ortho-bromobenzaldehyde (6630-33-7) → 2-(α-styryl)benzaldehyde (871563-46-1)

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; water; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.6b02825

upstream raw materials:

1-bromovinylbenzene

2-formylbenzene boronic acid

phenylvinylboronic acid

ortho-bromobenzaldehyde

Downstream raw materials:

3-phenyl-1-indanone

(R)-3-phenyl-2,3-dihydro-1H-inden-1-one

(S)-3-phenyl-2,3-dihydro-1H-inden-1-one

1-(3-phenyl-1H-inden-1-yl)propan-2-one