BOCCys(Bzl)TyrIleN₂H₃

Base Information

• Chemical Name: BOCCys(Bzl)TyrIleN₂H₃
• CAS No.: 124394-57-6
• Molecular Formula: C₃₀H₄₃N₅O₆S
• Molecular Weight: 601.767
• Mol file: 124394-57-6.mol

Synonyms:BOCCys(Bzl)TyrIleN₂H₃

Chemical Property of BOCCys(Bzl)TyrIleN₂H₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOCCys(Bzl)TyrIleN₂H₃

There total 6 articles about BOCCys(Bzl)TyrIleN₂H₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

BOCCys(Bzl)TyrIleOMe (124394-56-5) → BOCCys(Bzl)TyrIleN2H3 (124394-57-6)

Guidance literature:

hydrazinolysis;

DOI:10.1007/BF00598080

Reference yield:

L-isoleucine methyl ester (2577-46-0) → BOCCys(Bzl)TyrIleN2H3 (124394-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / N-hydroxysuccinimide (HOSu), dicyclohexylcarbodiimid (DCHC) / various solvent(s) / 0 °C

2: 87 percent / hydrogen / palladium black / methanol / 20 h / Ambient temperature

3: 92 percent / butyl chloroformate, TEA / diethyl ether / 1) -10 deg C, 30 min, 2) 0 deg C, 18 h

4: 61 percent / hydrazine hydrate / methanol / 18 h / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; TEA; hydrogen; hydrazine hydrate; carbonochloridic acid, butyl ester; dicyclohexyl-carbodiimide; palladium; In methanol; diethyl ether;

DOI:10.1007/BF00596712

Reference yield:

Z-L-Tyr-OH (1164-16-5) → BOCCys(Bzl)TyrIleN2H3 (124394-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / N-hydroxysuccinimide (HOSu), dicyclohexylcarbodiimid (DCHC) / various solvent(s) / 0 °C

2: 87 percent / hydrogen / palladium black / methanol / 20 h / Ambient temperature

3: 92 percent / butyl chloroformate, TEA / diethyl ether / 1) -10 deg C, 30 min, 2) 0 deg C, 18 h

4: 61 percent / hydrazine hydrate / methanol / 18 h / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; TEA; hydrogen; hydrazine hydrate; carbonochloridic acid, butyl ester; dicyclohexyl-carbodiimide; palladium; In methanol; diethyl ether;

DOI:10.1007/BF00596712

upstream raw materials:

BOCCys(Bzl)TyrIleOMe

(2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid

HTyr-IleOMe

L-isoleucine methyl ester