3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

Base Information

Chemical Name:3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid
CAS No.:1228102-50-8
Molecular Formula:C₂HF₃O₂*C₂₅H₂₅N₃OS
Molecular Weight:529.583
Hs Code.:

Synonyms:3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

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Chemical Property of 3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

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Technology Process of 3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

There total 10 articles about 3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1228103-34-1
N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

: 76-05-1
trifluoroacetic acid

: 1228102-50-8
3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

Guidance literature:: With methoxybenzene; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 69627-03-8
7-chlorothieno[3,2-b]pyridine

: 1228102-50-8
3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C

2.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

4.1: sodium acetate / 1,2-dichloro-ethane / 0.33 h

4.2: 5 h / 20 °C

5.1: methoxybenzene / dichloromethane / 15 h / 20 °C

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium acetate; sodium carbonate; methoxybenzene; diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: |Suzuki Coupling;

Reference yield:

: 69627-02-7
thieno[3,2-b]pyridin-7(4H)-one

: 1228102-50-8
3-(2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 6 h / Reflux

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C

3.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

4.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

5.1: sodium acetate / 1,2-dichloro-ethane / 0.33 h

5.2: 5 h / 20 °C

6.1: methoxybenzene / dichloromethane / 15 h / 20 °C

With n-butyllithium; oxalyl dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium acetate; sodium carbonate; methoxybenzene; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 4.1: |Suzuki Coupling;