N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

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Chemical Name:N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine
CAS No.:1228103-34-1
Molecular Formula:C₃₃H₃₃N₃O₂S
Molecular Weight:535.71
Hs Code.:

Synonyms:N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

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Chemical Property of N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

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Technology Process of N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

There total 10 articles about N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 110-89-4
piperidine

: 1228102-90-6
4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

: 1228103-34-1
N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

Guidance literature:: piperidine; 4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde; With sodium acetate; In 1,2-dichloro-ethane; for 0.333333h;

With sodium acetate; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 5h;

Reference yield:

: 69627-03-8
7-chlorothieno[3,2-b]pyridine

: 1228103-34-1
N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C

2.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

4.1: sodium acetate / 1,2-dichloro-ethane / 0.33 h

4.2: 5 h / 20 °C

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium acetate; sodium carbonate; diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: |Suzuki Coupling;

Reference yield:

: 913377-45-4
2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione

: 1228103-34-1
N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-(piperidin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenylether / 0.5 h / 259 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 6 h / Reflux

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 - 20 °C

4.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

6.1: sodium acetate / 1,2-dichloro-ethane / 0.33 h

6.2: 5 h / 20 °C

With n-butyllithium; oxalyl dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium acetate; sodium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diphenylether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 5.1: |Suzuki Coupling;