N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

Base Information

Chemical Name:N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide
CAS No.:1306720-97-7
Molecular Formula:C₂₁H₂₄N₄O₄S
Molecular Weight:428.512
Hs Code.:

Synonyms:N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

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Chemical Property of N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

Chemical Property:

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Technology Process of N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

There total 5 articles about N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 15197-75-8
3-(pyridin-2-yl)propanoic acid

: 1306720-32-0
N-[4-(piperazine-1-sulfonyl)phenyl]acrylamide

: 1306720-97-7
N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1306720-97-7
N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: ammonium chloride; iron / ethanol; water / 3 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 173951-83-2
N-((4-nitrophenyl)sulfonyl)-1-(tert-butyloxycarbonyl)piperazine

: 1306720-97-7
N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium chloride; iron / ethanol; water / 3 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;