15197-75-8

Basic information

• Product Name: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4
• Synonyms: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4;3-(2-Pyridinyl)propanoic acid;2-PYRIDINEPROPANOIC ACID;2-Pyridylpropanoic acid;3-Pyridin-2-yl-propionic acid sulfate;3-Pyridin-2-yl-propionic acid H2SO4 ,95%;3-pyridin-2-ylpropanoic acid(SALTDATA: 0.02Na2SO4);3-Pyridin-2-yl-propionic acid sulfuric acid
• CAS NO: 15197-75-8
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 249.24
• Product Categories: pharmacetical
• Mol File: 15197-75-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 140-145°C
• Boiling Point: 287.4°Cat760mmHg
• Flash Point: 127.6°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 4.8E-11mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.87±0.10(Predicted)
• CAS DataBase Reference: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4(15197-75-8)
• EPA Substance Registry System: 3-PYRIDIN-2-YL-PROPIONIC ACID H2SO4(15197-75-8)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 15197-75-8(Hazardous Substances Data)

Usage

General Description

3-Pyridin-2-yl-propionic acid H2SO4, also known as pirfenidone, is a synthetic compound that is used as a medication for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing the production of collagen and other proteins that contribute to the development and progression of fibrosis in the lungs. Its chemical structure consists of a pyridine ring with a propionic acid moiety attached to it, and it is commonly found in the form of a salt with sulfuric acid (H2SO4). Pirfenidone has been shown to slow down the decline in lung function and reduce the risk of disease progression in patients with IPF, making it an important therapeutic option for this debilitating condition.

InChI:InChI=1/C8H9NO2.H2O4S/c10-8(11)5-4-7-3-1-2-6-9-7;1-5(2,3)4/h1-3,6H,4-5H2,(H,10,11);(H2,1,2,3,4)

Upstream product

• 109-06-8 α-picoline 
• 2859-68-9 3-(pyridin-2-yl)-propanol 
• 2057-32-1 3-(pyridin-2-yl)propanal 
• 2739-74-4 ethyl 3-(2-pyridinyl)propanoate 
• 1121-60-4 pyridine-2-carbaldehyde 
• 67-66-3 chloroform 
• 10028-15-6 ozone 
• 7340-22-9 3-pyridin-2-yl-acrylic acid 
• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 35549-47-4 2-(2-Cyanoethyl)pyridine 

Downstream Products

• 20745-52-2 N-phenyl-3-pyridin-2-yl-propionamide 
• 28819-26-3 methyl 3-(pyridin-2-yl)propanoate 
• 116191-61-8 1-Hydroxy-3-(piperidin-2-yl)-propane-1,1-diphosphonic acid 
• 99310-43-7 3-[2]piperidyl-propionic acid ; hydrochloride 
• 1019649-25-2 N-(4-(2-oxo-4-phenylpyrrolidin-1-yl)pyridin-2-yl)-3-(pyridin-2-yl)propanamide 
• 1416797-69-7 (S)-3-(pyridin-2-yl)-N-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)propanamide 
• 1306720-97-7 N-{4-[4-(3-pyridin-3-yl-propionyl)-piperazine-1-sulfonyl]-phenyl}-acrylamide 

Relevant articles and documents

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Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations

An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.

KetoABNO/NOx Cocatalytic Aerobic Oxidation of Aldehydes to Carboxylic Acids and Access to α-Chiral Carboxylic Acids via Sequential Asymmetric Hydroformylation/Oxidation

A method for aerobic oxidation of aldehydes to carboxylic acids has been developed using organic nitroxyl and NOx cocatalysts. KetoABNO (9-azabicyclo[3.3.1]nonan-3-one N-oxyl) and NaNO2 were identified as the optimal nitroxyl and NOx sources, respectively. The mildness of the reaction conditions enables sequential asymmetric hydroformylation of alkenes/aerobic aldehyde oxidation to access α-chiral carboxylic acids without racemization. The scope, utility, and limitations of the oxidation method are further evaluated with a series of achiral aldehydes bearing diverse functional groups.