2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

Base Information

Chemical Name:2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde
CAS No.:914301-49-8
Molecular Formula:C₁₅H₁₂FNO₄
Molecular Weight:289.263
Hs Code.:

Synonyms:2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

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Chemical Property of 2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

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Technology Process of 2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

There total 10 articles about 2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 914301-48-7
[2-fluoro-3-(4-methoxybenzyl)-5-nitrophenyl]methanol

: 914301-49-8
2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - -30 ℃;
DOI:10.1021/jm051222g

Reference yield:

: 443-88-9
2-fluoro-m-xylene

: 914301-49-8
2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 58 percent / KMnO₄; KOH / H₂O / Heating

2: 40 percent / H₂SO₄ / 48 h / 20 °C

3: 99 percent / HNO₃; H₂SO₄ / 2 h / 20 °C

4: SOCl₂ / 3 h / Heating

5: 3.24 g / AlCl₃ / 20 h / 20 °C

6: 98 percent / TFA; trifluoromethanesulfonic acid; Et₃SiH / CH₂Cl₂ / 6 h / 50 °C

7: 61 percent / NaBH₄ / dioxane; H₂O / 20 °C

8: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -30 °C

With triethylsilane; potassium hydroxide; sodium tetrahydroborate; potassium permanganate; aluminium trichloride; thionyl chloride; oxalyl dichloride; trifluorormethanesulfonic acid; sulfuric acid; nitric acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 5: Friedel-Crafts acylation / 8: Swern oxidation;
DOI:10.1021/jm051222g

Reference yield:

: 1583-65-9
2-fluoro-isophthalic acid

: 914301-49-8
2-fluoro-3-(4-methoxybenzyl)-5-nitrobenzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 40 percent / H₂SO₄ / 48 h / 20 °C

2: 99 percent / HNO₃; H₂SO₄ / 2 h / 20 °C

3: SOCl₂ / 3 h / Heating

4: 3.24 g / AlCl₃ / 20 h / 20 °C

5: 98 percent / TFA; trifluoromethanesulfonic acid; Et₃SiH / CH₂Cl₂ / 6 h / 50 °C

6: 61 percent / NaBH₄ / dioxane; H₂O / 20 °C

7: 99 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -30 °C

With triethylsilane; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; oxalyl dichloride; trifluorormethanesulfonic acid; sulfuric acid; nitric acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 4: Friedel-Crafts acylation / 7: Swern oxidation;
DOI:10.1021/jm051222g