Technology Process of 2-[2-fluoro-3-(4-methoxy-benzyl)-5-nitro-benzylamino]-ethanol
There total 11 articles about 2-[2-fluoro-3-(4-methoxy-benzyl)-5-nitro-benzylamino]-ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride; acetic acid;
In
methanol;
for 3h;
Heating;
DOI:10.1021/jm051222g
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 58 percent / KMnO4; KOH / H2O / Heating
2: 40 percent / H2SO4 / 48 h / 20 °C
3: 99 percent / HNO3; H2SO4 / 2 h / 20 °C
4: SOCl2 / 3 h / Heating
5: 3.24 g / AlCl3 / 20 h / 20 °C
6: 98 percent / TFA; trifluoromethanesulfonic acid; Et3SiH / CH2Cl2 / 6 h / 50 °C
7: 61 percent / NaBH4 / dioxane; H2O / 20 °C
8: 99 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -30 °C
9: 75 percent / NaCNBH3; AcOH / methanol / 3 h / Heating
With
triethylsilane; potassium hydroxide; sodium tetrahydroborate; potassium permanganate; aluminium trichloride; thionyl chloride; oxalyl dichloride; trifluorormethanesulfonic acid; sulfuric acid; nitric acid; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; dichloromethane; water;
5: Friedel-Crafts acylation / 8: Swern oxidation;
DOI:10.1021/jm051222g
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 40 percent / H2SO4 / 48 h / 20 °C
2: 99 percent / HNO3; H2SO4 / 2 h / 20 °C
3: SOCl2 / 3 h / Heating
4: 3.24 g / AlCl3 / 20 h / 20 °C
5: 98 percent / TFA; trifluoromethanesulfonic acid; Et3SiH / CH2Cl2 / 6 h / 50 °C
6: 61 percent / NaBH4 / dioxane; H2O / 20 °C
7: 99 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -30 °C
8: 75 percent / NaCNBH3; AcOH / methanol / 3 h / Heating
With
triethylsilane; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; oxalyl dichloride; trifluorormethanesulfonic acid; sulfuric acid; nitric acid; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; dichloromethane; water;
4: Friedel-Crafts acylation / 7: Swern oxidation;
DOI:10.1021/jm051222g
