2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

Base Information

Chemical Name:2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid
CAS No.:1354721-78-0
Molecular Formula:C₄₀H₄₇F₃N₆O₇
Molecular Weight:780.844
Hs Code.:

2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

Synonyms:2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

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Chemical Property of 2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

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Technology Process of 2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

There total 9 articles about 2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1354722-29-4
C₄₄H₅₅F₃N₆O₇

: 1354721-78-0
2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-78-0
2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

6: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With copper(l) iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; L-proline; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

: 1354721-78-0
2-methyl-1-(3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)phenyl)-5,8,11-trioxa-2-azatetradecan-14-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C

2: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;