1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

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Chemical Name:1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea
CAS No.:1455035-05-8
Molecular Formula:C₂₆H₂₆FN₅O
Molecular Weight:443.524
Hs Code.:

Synonyms:1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

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Chemical Property of 1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

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Technology Process of 1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

There total 2 articles about 1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1455038-83-1
prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

: 64-04-0
phenethylamine

: 1455035-05-8
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

Guidance literature:: prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate; phenethylamine; With 1-Methylpyrrolidine; In 1,4-dioxane; at 50 ℃;

With sodium hydroxide; In 1,4-dioxane; at 20 - 60 ℃;

Reference yield:

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

: 1455035-05-8
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 1 h / 0 °C

2.1: 1-Methylpyrrolidine / 1,4-dioxane / 50 °C

2.2: 20 - 60 °C

With 1-Methylpyrrolidine; pyridine; In 1,4-dioxane; 1.1: |Schotten-Baumann Reaction;