prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate
CAS No.:1455038-83-1
Molecular Formula:C₂₅H₂₅FN₄O₄
Molecular Weight:464.496
Hs Code.:

Synonyms:prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

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Chemical Property of prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

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Technology Process of prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

There total 1 articles about prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 57933-83-2
Isopropenyl chloroformate

: 1455036-26-6
3-(5-amino-4-fluoro-2-methyl-phenyl)-N, 2-dimethyl-1,6-naphthyridin-7-amine

: 1455038-83-1
prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

Guidance literature:: With pyridine; at 0 ℃; for 1h;

Reference yield: 77.0%

: 1455038-83-1
prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

: 64-04-0
phenethylamine

: 1455035-05-8
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea

Guidance literature:: prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate; phenethylamine; With 1-Methylpyrrolidine; In 1,4-dioxane; at 50 ℃;

With sodium hydroxide; In 1,4-dioxane; at 20 - 60 ℃;

Reference yield:

: 1455038-83-1
prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(((prop-1-en-2-yloxy)carbonyl)amino)phenyl)-2-methyl-1,6-naphthyridin-7-yl)(methyl)carbamate

: 1455033-31-4
1-(2-fluoro-4-methyl-5-(2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl)phenyl)-3-phenethylurea hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-Methylpyrrolidine / 1,4-dioxane / 50 °C

1.2: 20 - 60 °C

2.1: hydrogenchloride / acetonitrile

With 1-Methylpyrrolidine; hydrogenchloride; In 1,4-dioxane; acetonitrile;