1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Base Information

Chemical Name:1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole
CAS No.:155261-42-0
Molecular Formula:C₂₁H₂₁N₃O₂
Molecular Weight:347.417
Hs Code.:

Synonyms:1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

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Chemical Property of 1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Chemical Property:

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Technology Process of 1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

There total 4 articles about 1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 155261-30-6,180975-33-1
3-(pyridin-2-yl)-4,5,6,7-tetrahydro-2H-indazole

: 155261-42-0
1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 120 - 140 ℃; for 72h;
DOI:10.1021/jo00086a028

Reference yield:

: 29745-44-6
pyridine-2-carbonyl chloride

: 155261-42-0
1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / Ambient temperature

2: 94 percent / hydrazine hydrate / CH₂Cl₂

3: 52 percent / K₂CO₃ / dimethylsulfoxide / 72 h / 120 - 140 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00086a028

Reference yield:

: 98-98-6
2-Picolinic acid

: 155261-42-0
1-<4-(Ethoxycarbonyl)phenyl>-3-(pyridin-2-yl)-4,5,6,7-tetrahydroindazole

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / tetrahydrofuran / Ambient temperature

3: 94 percent / hydrazine hydrate / CH₂Cl₂

4: 52 percent / K₂CO₃ / dimethylsulfoxide / 72 h / 120 - 140 °C

With thionyl chloride; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00086a028