(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

Base Information

Chemical Name:(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol
CAS No.:149882-16-6
Molecular Formula:C₁₁H₁₁F₂N₃O₂
Molecular Weight:255.224
Hs Code.:

Synonyms:(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

Chemical Property:

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Technology Process of (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

There total 8 articles about (S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86386-74-5
1,3-(dichloro)-2-(2,4-difluorophenyl)propan-2-ol

: 149882-16-6
(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium hydroxymethanesulfinate dihydrate; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / Inert atmosphere

3: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / Inert atmosphere

4: potassium carbonate / tetrahydrofuran / Reflux

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; sodium hydroxymethanesulfinate dihydrate; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; N,N-dimethyl-formamide; 3: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/cjoc.201300430

Reference yield:

: 164347-62-0
1,2-epoxy-3-chloro-2-(2,4-difluorophenyl)-propane

: 149882-16-6
(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxymethanesulfinate dihydrate; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / Inert atmosphere

2: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / Inert atmosphere

3: potassium carbonate / tetrahydrofuran / Reflux

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; sodium hydroxymethanesulfinate dihydrate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; 2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/cjoc.201300430

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 149882-16-6
(S)-(+)-2-(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: sodium hydroxymethanesulfinate dihydrate; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / Inert atmosphere

4.1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / Inert atmosphere

5.1: potassium carbonate / tetrahydrofuran / Reflux

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; diethyl (2R,3R)-tartrate; sodium hydroxymethanesulfinate dihydrate; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; n-heptane; dichloromethane; N,N-dimethyl-formamide; 4.1: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/cjoc.201300430