(R)-2-(2,4-Difluorophenyl)oxirane-2-methanol

Base Information

Chemical Name:(R)-2-(2,4-Difluorophenyl)oxirane-2-methanol
CAS No.:141113-39-5
Molecular Formula:C9H8F2O2
Molecular Weight:186.158
Hs Code.:
DSSTox Substance ID:DTXSID101255146
Nikkaji Number:J2.000.461D
Mol file:141113-39-5.mol

Synonyms:141113-39-5;SCHEMBL8106827;DTXSID101255146;(2R)-2-(2,4-Difluorophenyl)-2-oxiranemethanol

Suppliers and Price of (R)-2-(2,4-Difluorophenyl)oxirane-2-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (R)-2-(2,4-Difluorophenyl)oxirane-2-methanol

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:186.04923582
Heavy Atom Count:13
Complexity:200

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(O1)(CO)C2=C(C=C(C=C2)F)F
Isomeric SMILES:C1[C@](O1)(CO)C2=C(C=C(C=C2)F)F

Technology Process of (R)-2-(2,4-Difluorophenyl)oxirane-2-methanol

There total 6 articles about (R)-2-(2,4-Difluorophenyl)oxirane-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 506439-68-5
(R)-3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol

: 141113-39-5
(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/j.tet.2003.10.119

Reference yield:

: 164347-62-0
1,2-epoxy-3-chloro-2-(2,4-difluorophenyl)-propane

: 141113-39-5
(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / Aspergillus niger / H₂O; aq. phosphate buffer / 4.75 h / 27 °C

2: 96 percent / NaH / tetrahydrofuran / 2 h / 0 °C

With Aspergillus niger; sodium hydride; In tetrahydrofuran; phosphate buffer; water;
DOI:10.1016/j.tet.2003.10.119

Reference yield:

: 141113-36-2
2-(2,4-difluorophenyl)allyl alcohol

: 141113-39-5
(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; In n-heptane; dichloromethane; at -20 ℃; Inert atmosphere;
DOI:10.1002/cjoc.201300430