86386-74-5 Usage
Explanation
Different sources of media describe the Explanation of 86386-74-5 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 9 carbon (C), 9 hydrogen (H), 2 chlorine (Cl), 2 fluorine (F), and 1 oxygen (O) atoms.
2. The compound contains an alcohol group (-OH) attached to the second carbon of the propan-2-ol molecule, two chlorine atoms, two fluorine atoms, and a phenyl group.
3. The structural formula shows the arrangement of atoms in the molecule. In this case, the molecule has a 1,3-dichloro substitution on the first carbon, a 2,4-difluorophenyl group attached to the second carbon, and a hydroxyl group (-OH) attached to the third carbon.
4. The compound is derived from propan-2-ol (isopropanol or rubbing alcohol) by introducing two chlorine atoms and two fluorine atoms into its structure.
5. Due to its unique chemical structure and properties, the compound is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals.
6. The compound's applications in the synthesis of pharmaceuticals and agrochemicals make it relevant to the fields of medicine and agriculture.
7. The compound's molecular weight and the presence of multiple functional groups suggest that it is likely to be a liquid or solid at room temperature, although the exact physical state is not provided in the material.
8. The compound is likely to be stable under normal conditions, as it is used as an intermediate in the synthesis of other compounds. However, the specific stability of the compound is not provided in the material.
Functional groups
Alcohol (-OH), Chlorine (-Cl), Fluorine (-F), and Phenyl (C6H5)
Type of compound
Chlorinated and fluorinated derivative of propan-2-ol
Applications
Pharmaceutical and agrochemical synthesis
Potential fields
Medicine and agriculture
Physical state
Likely a liquid or solid at room temperature
Polarity
Polar
Solubility
Soluble in organic solvents, potentially soluble in water
Stability
Stable under normal conditions
Check Digit Verification of cas no
The CAS Registry Mumber 86386-74-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,8 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86386-74:
(7*8)+(6*6)+(5*3)+(4*8)+(3*6)+(2*7)+(1*4)=175
175 % 10 = 5
So 86386-74-5 is a valid CAS Registry Number.
86386-74-5Relevant articles and documents
Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates
Von Keutz, Timo,Cantillo, David,Kappe, C. Oliver
supporting information, p. 7537 - 7541 (2020/10/12)
The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).
Asymmetric synthesis, antifungal activity and molecular modeling of iodiconazole isomers
Zhang, Yongqiang,Wang, Shengzheng,Miao, Zhenyuan,Yao, Jianzhong,Zhang, Wannian,Sheng, Chunquan
, p. 1139 - 1143 (2013/10/21)
Iodiconazole is a novel antifungal agent that was developed in its racemic form. In order to investigate the effects of the chiral center on the antifungal activity, R- and S-isomers of iodiconazole were prepared on the basis of the asymmetric Sharpless epoxidation. (S)-Iodiconazole was proved to have better antifungal activity than the (R)-isomer. The binding modes of the two isomers with lanosterol 14α-demethylase were clarified by molecular docking. Two isomers of iodiconazole, a novel antifungal agent, were prepared by asymmetric synthesis. Their antifungal activity and binding modes were investigated. Copyright
A practical chemoenzymatic synthesis of a key intermediate of antifungal agents
Yasohara, Yoshihiko,Miyamoto, Kenji,Kizaki, Noriyuku,Hasegawa, Junzo,Ohashi, Takehisa
, p. 3331 - 3333 (2007/10/03)
A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.
