1,4-Dibenzoylpiperazine

Base Information

• Chemical Name: 1,4-Dibenzoylpiperazine
• CAS No.: 6091-41-4
• Molecular Formula: C18H18N2O2
• Molecular Weight: 294.353
• Hs Code.: 2933599090
• European Community (EC) Number: 621-705-5
• NSC Number: 23580
• UNII: 964Y2A1KU8
• DSSTox Substance ID: DTXSID70209745
• Nikkaji Number: J50.586B
• Wikidata: Q27271866
• ChEMBL ID: CHEMBL1330660
• Mol file: 6091-41-4.mol

Synonyms:N,N'-dibenzoylpiperazine

Chemical Property of 1,4-Dibenzoylpiperazine

Chemical Property:

• PSA: 40.62000
• LogP: 2.16060
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 294.136827821
• Heavy Atom Count: 22
• Complexity: 352

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(CCN1C(=O)C2=CC=CC=C2)C(=O)C3=CC=CC=C3

Technology Process of 1,4-Dibenzoylpiperazine

There total 23 articles about 1,4-Dibenzoylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

piperazine (110-85-0) + benzoic acid (65-85-0,8013-63-6) → 1,4-dibenzoylpiperazine (6091-41-4)

Guidance literature:

With nickel ferrite nanoparticle; In neat (no solvent); for 0.166667h; Irradiation; Sealed tube;

DOI:10.1039/c2ob26930a

Reference yield: 92.0%

piperazine (110-85-0) + benzaldehyde (100-52-7) → 1,4-dibenzoylpiperazine (6091-41-4)

Guidance literature:

piperazine; With C₅₆H₈₆F₂Li₂N₃O₄Si₂Sm; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere; Glovebox;

benzaldehyde; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere; Glovebox;

DOI:10.1039/c5ra20285j

Reference yield: 86.0%

1,4-dithiobenzoylpiperazine (6391-95-3) → 1,4-dibenzoylpiperazine (6091-41-4)

Guidance literature:

With ammonium cerium(IV) nitrate; acetic acid; In water; at 20 ℃; for 0.25h;

upstream raw materials:

piperazine

benzoyl chloride

Benzoic trimethylacetic anhydride

1,4-dithiobenzoylpiperazine

Downstream raw materials:

1,4-dithiobenzoylpiperazine

N,N'-dibenzylpiperazine

(4-benzyl-1-piperazinyl)(phenyl)methanone

benzoic acid phenyl ester