4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester

Base Information

• Chemical Name: 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester
• CAS No.: 1333471-42-3
• Molecular Formula: C₁₄H₁₈O₆
• Molecular Weight: 282.293
• Mol file: 1333471-42-3.mol

Synonyms:4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester

Chemical Property of 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester

There total 1 articles about 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,3-benzenedicarboxylic acid 2-hydroxy-4,6-dimethyl-1,3-dimethyl ester (76716-11-5) + chloromethyl methyl ether (107-30-2) → 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-42-3)

Guidance literature:

1,3-benzenedicarboxylic acid 2-hydroxy-4,6-dimethyl-1,3-dimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1039/c1dt10556f

Reference yield: 54.0%

N-Bromosuccinimide (128-08-5) + 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-42-3) → 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-44-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In dichloromethane; at 25 ℃; for 1h; Inert atmosphere; Irradiation;

DOI:10.1039/c1dt10556f

Reference yield:

4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-42-3) → 2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenol (1333471-52-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2,2'-azobis(isobutyronitrile) / dichloromethane / 1 h / 25 °C / Inert atmosphere; Irradiation

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.58 h / -78 °C / Inert atmosphere

4.2: 0 - 25 °C / Inert atmosphere

5.1: hydrogenchloride; methanol / 2 h / 25 °C / Inert atmosphere

With hydrogenchloride; methanol; lithium aluminium tetrahydride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; mineral oil; 4.1: Swern oxidation / 4.2: Swern oxidation;

DOI:10.1039/c1dt10556f

upstream raw materials:

1,3-benzenedicarboxylic acid 2-hydroxy-4,6-dimethyl-1,3-dimethyl ester

chloromethyl methyl ether

Downstream raw materials:

4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester

2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenol

2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenyl trifluoromethanesulfonate

2-methoxymethoxy-4,6-bis(2,5,8,11-tetraoxadodecyl)isophthalic acid dimethyl ester

Refernces