4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester

Base Information

• Chemical Name: 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester
• CAS No.: 1333471-44-5
• Molecular Formula: C₁₄H₁₆Br₂O₆
• Molecular Weight: 440.085
• Mol file: 1333471-44-5.mol

Synonyms:4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester

Chemical Property of 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester

There total 2 articles about 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-Bromosuccinimide (128-08-5) + 4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-42-3) → 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-44-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In dichloromethane; at 25 ℃; for 1h; Inert atmosphere; Irradiation;

DOI:10.1039/c1dt10556f

Reference yield:

1,3-benzenedicarboxylic acid 2-hydroxy-4,6-dimethyl-1,3-dimethyl ester (76716-11-5) → 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile) / dichloromethane / 1 h / 25 °C / Inert atmosphere; Irradiation

With 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c1dt10556f

Reference yield: 67.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) + 4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester (1333471-44-5) → 2-methoxymethoxy-4,6-bis(2,5,8,11-tetraoxadodecyl)isophthalic acid dimethyl ester (1333471-46-7)

Guidance literature:

triethylene glucol monomethyl ether; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

4,6-bis(bromomethyl)-2-methoxymethoxyisophthalic acid dimethyl ester; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

DOI:10.1039/c1dt10556f

upstream raw materials:

N-Bromosuccinimide

4,6-dimethyl-2-methoxymethoxyisophthalic acid dimethyl ester

1,3-benzenedicarboxylic acid 2-hydroxy-4,6-dimethyl-1,3-dimethyl ester

Downstream raw materials:

2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenol

2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenyl trifluoromethanesulfonate

2,6-dihydroxymethyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenyl methoxymethyl ether

2,6-diformyl-3,5-bis(2,5,8,11-tetraoxadodecyl)phenyl methoxymethyl ether