N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Base Information

• Chemical Name: N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine
• CAS No.: 745795-93-1
• Molecular Formula: C₆₇H₇₅N₃O₉Si
• Molecular Weight: 1094.43
• Mol file: 745795-93-1.mol

Synonyms:N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Chemical Property of N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine

There total 3 articles about N-(N^α,N^ε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-2,N-6-bis(9-fluorenylmethyloxycarbonyl)-L-lysine (75932-02-4,78081-87-5) + 2-(bis(4-methoxyphenyl)(phenyl)methoxy)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)ethan- 1-amine (745795-94-2) → N-(Nα,Nε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine (745795-93-1)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/ja049061d

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-(Nα,Nε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine (745795-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 80 percent / PyBOP; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja049061d

Reference yield:

O-(4,4'-dimethoxytrityl)diethanolamine (516462-74-1) → N-(Nα,Nε-bis-Fmoc-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine (745795-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 80 percent / PyBOP; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja049061d

upstream raw materials:

N-2,N-6-bis(9-fluorenylmethyloxycarbonyl)-L-lysine

2-(bis(4-methoxyphenyl)(phenyl)methoxy)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)ethan- 1-amine

tert-butyldimethylsilyl chloride

O-(4,4'-dimethoxytrityl)diethanolamine

Refernces