Technology Process of allyl 2-oxo-2-(p-tolyl)acetate
There total 3 articles about allyl 2-oxo-2-(p-tolyl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-methylphenyl)(oxo)acetic acid; allyl alcohol;
With
dmap;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
for 6h;
Inert atmosphere;
DOI:10.1002/chem.201102584
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere
3.1: acetic acid; tetra-(n-butyl)ammonium iodide / acetonitrile / 12 h / 20 °C / Electrochemical reaction; Green chemistry
With
4-acetamidobenzenesulfonyl azide; tetra-(n-butyl)ammonium iodide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; acetonitrile;
DOI:10.1039/d1cc06945d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere
2: acetic acid; tetra-(n-butyl)ammonium iodide / acetonitrile / 12 h / 20 °C / Electrochemical reaction; Green chemistry
With
4-acetamidobenzenesulfonyl azide; tetra-(n-butyl)ammonium iodide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
DOI:10.1039/d1cc06945d
