N-benzyl-N'-(2'-acetamido)thiourea

Base Information

• Chemical Name: N-benzyl-N'-(2'-acetamido)thiourea
• CAS No.: 1399859-85-8
• Molecular Formula: C₁₀H₁₃N₃OS
• Molecular Weight: 223.299
• Mol file: 1399859-85-8.mol

Synonyms:N-benzyl-N'-(2'-acetamido)thiourea

Chemical Property of N-benzyl-N'-(2'-acetamido)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N'-(2'-acetamido)thiourea

There total 1 articles about N-benzyl-N'-(2'-acetamido)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.98%

glycinamide hydrochloride (1668-10-6) + potassium thioacyanate (333-20-0) + benzyl chloride (100-44-7) → N-benzyl-N'-(2'-acetamido)thiourea (1399859-85-8)

Guidance literature:

potassium thioacyanate; benzyl chloride; With bis(triphenylphosphine)iminium chloride; In 1,2-dichloro-benzene; at 180 ℃; for 3h;

glycinamide hydrochloride; With potassium hydroxide; In ethanol; water; at -30 - 0 ℃; pH=8.5;

DOI:10.3390/molecules19011023

Reference yield: 78.1%

N-benzyl-N'-(2'-acetamido)thiourea (1399859-85-8) → 3-benzyl-2-thioxotetrahydro-4H-imidazol-4-one (39123-65-4)

Guidance literature:

With hydrogenchloride; In acetone; at 40 ℃;

DOI:10.3390/molecules19011023

Reference yield:

N-benzyl-N'-(2'-acetamido)thiourea (1399859-85-8) → C26H23N3O2

Guidance literature:

Multi-step reaction with 11 steps

1.1: hydrogenchloride / acetone / 40 °C

2.1: potassium carbonate / acetonitrile / 14 h / 40 °C

3.1: tetrahydrofuran / 0.17 h / 20 °C

4.1: boron trifluoride diethyl etherate / benzene / 2 h / 20 °C / Inert atmosphere

5.1: sulfuric acid / 24 h / 0 °C / Reflux

6.1: sodium thioethylate / N,N-dimethyl-formamide / Reflux

7.1: sodium nitrite; nitric acid / water / 0.5 h

7.2: Heating

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.75 h / Inert atmosphere

9.1: thionyl chloride / 3 h / Reflux

10.1: potassium hydroxide; 2,7-bis[O-9-allylhydrocinchonidinium-N-methyl]naphthalene dibromide / water; toluene / 8 h / 0 °C

11.1: citric acid / water; tetrahydrofuran

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; 2,7-bis[O-9-allylhydrocinchonidinium-N-methyl]naphthalene dibromide; sulfuric acid; boron trifluoride diethyl etherate; nitric acid; potassium carbonate; citric acid; potassium hydroxide; sodium nitrite; sodium thioethylate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene; 10.1: |O'Donnell Amino Acid Synthesis;

DOI:10.3390/molecules19011023

upstream raw materials:

glycinamide hydrochloride

potassium thioacyanate

benzyl chloride

Downstream raw materials:

ethyl 1-benzyl-1H-imidazole-5-carboxylic acid

1-Benzyl-5-(chloromethyl)-1H-imidazolium chloride

3-benzyl-2-thioxotetrahydro-4H-imidazol-4-one

1-benzyl-5-hydroxymethylimidazole

Refernces