7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

Base Information

Chemical Name:7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile
CAS No.:167159-35-5
Molecular Formula:C₃₃H₄₅ClN₂O₄S
Molecular Weight:601.25
Hs Code.:

Synonyms:7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

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Chemical Property of 7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

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Technology Process of 7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

There total 6 articles about 7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 80-41-1
2-chloroethyl tosylate

: 167159-34-4
α-(Cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolineheptanenitrile

: 167159-35-5
7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

Guidance literature:: With sodium hydroxide; In butanone; for 18h; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 1569-69-3
Cyclohexanethiol

: 167159-35-5
7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 79 percent / diisopropylethylamine, NaI / acetonitrile / Heating

4: 76 percent / 1 N NaOH / butan-2-one / 18 h / Heating

With sodium hydroxide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; butanone;
DOI:10.1021/jm9804477

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167159-35-5
7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) DMSO, 25 deg C, 1.5 h, 2.) DMSO, 25 deg C, 3 h

3: 79 percent / diisopropylethylamine, NaI / acetonitrile / Heating

4: 76 percent / 1 N NaOH / butan-2-one / 18 h / Heating

With sodium hydroxide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; butanone;
DOI:10.1021/jm9804477