methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Base Information

Chemical Name:methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid
CAS No.:1610889-90-1
Molecular Formula:C₁₆H₁₄F₃NO₂S
Molecular Weight:341.354
Hs Code.:

Synonyms:methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Suppliers and Price of methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

There total 6 articles about methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1242643-05-5
1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene

: 1610889-89-8
4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester

: 1610889-90-1
methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

: 1610890-01-1
ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: methanol; 4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester; With sodium; at 70 ℃; for 2h;

1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene; With potassium carbonate; In acetone; at 70 ℃; for 2.5h;

Reference yield:

: 347-93-3
3-chloro-4'-fluoropropiophenone

: 1610889-90-1
methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium iodide; sodium acetate / 16 h / 130 °C / Sealed tube

2.1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 0 - 23 °C

3.1: pyridine hydrogenfluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / dichloromethane / 3.5 h / -78 - 23 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 0 - 23 °C

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 1 h / 0 - 23 °C

6.1: sodium methylate / 1.5 h / 70 °C

6.2: 2.5 h / 70 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; boron trifluoride diethyl etherate; water; sodium methylate; sodium acetate; pyridine hydrogenfluoride; triphenylphosphine; potassium iodide; sodium hydroxide; In ethanol; dichloromethane;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-90-1
methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 0 - 23 °C

2.1: pyridine hydrogenfluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / dichloromethane / 3.5 h / -78 - 23 °C

3.1: sodium hydroxide; water / ethanol / 1 h / 0 - 23 °C

4.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 1 h / 0 - 23 °C

5.1: sodium methylate / 1.5 h / 70 °C

5.2: 2.5 h / 70 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; boron trifluoride diethyl etherate; water; sodium methylate; pyridine hydrogenfluoride; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane;