ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Base Information

Chemical Name:ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid
CAS No.:1610890-01-1
Molecular Formula:C₁₇H₁₆F₃NO₂S
Molecular Weight:355.381
Hs Code.:

Synonyms:ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

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Chemical Property of ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

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Technology Process of ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

There total 9 articles about ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1242643-05-5
1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene

: 1610889-89-8
4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester

: 1610889-90-1
methyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

: 1610890-01-1
ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: methanol; 4-(2-methoxycarbonylethylsulfanyl)pyridine-3-carboxylic acid ethyl ester; With sodium; at 70 ℃; for 2h;

1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene; With potassium carbonate; In acetone; at 70 ℃; for 2.5h;

Reference yield:

: 100791-00-2
4-chloronicotinoyl chloride

: 1610890-01-1
ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 4 h / 0 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: sodium / 2 h / 70 °C

3.2: 2.5 h / 70 °C

With potassium tert-butylate; sodium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 10177-29-4
4-chloronicotinic acid

: 1610890-01-1
ethyl esters of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 1.5 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / 4 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: sodium / 2 h / 70 °C

4.2: 2.5 h / 70 °C

With thionyl chloride; potassium tert-butylate; sodium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;