5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

Base Information

Chemical Name:5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate
CAS No.:250267-05-1
Molecular Formula:C₁₇H₂₈O₃
Molecular Weight:280.408
Hs Code.:

Synonyms:5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

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Chemical Property of 5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

Chemical Property:

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Technology Process of 5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

There total 12 articles about 5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 250267-02-8
3-[2-isopropyl-5-methylcyclohexyloxy(1R,2S,5R)]-2E-propenal

: 250267-05-1
5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

3-[2-isopropyl-5-methylcyclohexyloxy(1R,2S,5R)]-2E-propenal; In tetrahydrofuran; at -78 - 20 ℃; for 3h;
DOI:10.1016/S0040-4020(99)00666-3

Reference yield:

: 108167-50-6
ethynyl, [2-isopropyl-5-methylcyclohexyl(1R,2S,5R)]ether

: 250267-05-1
5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 57 percent / tetrakis(triphenylphosphine)palladium; copper(I) iodide; isopropylamine

2.1: 52 percent / H₂; Ni(OAc)2; sodium borohydride, ethylenediamine / ethanol / 1 h

3.1: 99 percent / tetraphenylporphyrin; ¹O₂ / CH₂Cl₂ / 0.17 h / 0 °C / Irradiation

4.1: NaHMDS / tetrahydrofuran / 0.17 h / -78 °C

4.2: tetrahydrofuran / 3 h / -78 - 20 °C

With sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; oxygen; sodium hexamethyldisilazane; nickel diacetate; 5,15,10,20-tetraphenylporphyrin; isopropylamine; ethylenediamine; In tetrahydrofuran; ethanol; dichloromethane; 1.1: Substitution / 2.1: Hydrogenation / 3.1: Oxidation / 4.1: Metallation / 4.2: Condensation;
DOI:10.1016/S0040-4020(99)00666-3

Reference yield:

: 2216-51-5
(-)-menthol

: 250267-05-1
5-ethyl 3-[2-isopropyl-5-methylcyclohexyloxy-(1R,2S,5R)]-2E,4E-pentadienoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 54 percent / Et₃N / diethyl ether / 15 h

2.1: 73 percent / DIBAL / diethyl ether; hexane / -78 °C

3.1: 100 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate / CH₂Cl₂ / 0.75 h / 20 °C

4.1: NaHMDS / tetrahydrofuran / 0.17 h / -78 °C

4.2: tetrahydrofuran / 3 h / -78 - 20 °C

With tetrapropylammonium perruthennate; sodium hexamethyldisilazane; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1.1: Addition / 2.1: Reduction / 3.1: Oxidation / 4.1: Metallation / 4.2: Condensation;
DOI:10.1016/S0040-4020(99)00666-3