1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

Base Information

Chemical Name:1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea
CAS No.:1439684-51-1
Molecular Formula:C₂₂H₁₉F₆N₅O₃
Molecular Weight:515.415
Hs Code.:

Synonyms:1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

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Chemical Property of 1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

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Technology Process of 1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

There total 3 articles about 1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1439684-19-1
methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

: 74-89-5
methylamine

: 1439684-51-1
1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

Guidance literature:: In methanol; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 1257599-55-5
C₁₂H₇F₆N₃O

: 1439684-51-1
1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: water; methanol / 1 h / 20 °C

With potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 3862-73-5
2,3,4-trifluoroaniline

: 1439684-51-1
1-methoxy-3-methyl-1-(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; hydrogenchloride / water

2: toluene / Reflux; Dean-Stark

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

4: water; methanol / 1 h / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.04.045