methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

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Chemical Name:methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate
CAS No.:1439684-19-1
Molecular Formula:C₂₂H₁₈F₆N₄O₄
Molecular Weight:516.4
Hs Code.:

Synonyms:methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

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Chemical Property of methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

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Technology Process of methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

There total 2 articles about methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1257599-55-5
C₁₂H₇F₆N₃O

: C₁₁H₁₄BrNO₃

: 1439684-19-1
methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 3862-73-5
2,3,4-trifluoroaniline

: 1439684-19-1
methyl methoxy(2-(((5-methyl-6-(trifluoromethyl)-2-((2,3,4-trifluorophenyl)amino)pyrimidin-4-yl)oxy)methyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; hydrogenchloride / water

2: toluene / Reflux; Dean-Stark

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.04.045