5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Base Information

• Chemical Name: 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
• CAS No.: 1213702-53-4
• Molecular Formula: C₂₂H₂₁BrN₂O₂
• Molecular Weight: 425.325
• Mol file: 1213702-53-4.mol

Synonyms:5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Chemical Property of 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

There total 3 articles about 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

ethyl bromide (74-96-4) + 5-[3-(4-bromophenyl)-2-propenoyl]-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (924724-65-2) → 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (1213702-53-4)

Guidance literature:

With potassium hydroxide; In acetonitrile; for 1h; Reflux;

DOI:10.1080/00397911.2013.869341

Reference yield:

5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (25652-50-0) → 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (1213702-53-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 1 h / 60 °C

1.2: 1.5 h / 20 - 60 °C

2.1: potassium hydroxide / methanol / 3.5 h / 20 °C

3.1: sulfuric acid / 1,4-dioxane

4.1: potassium hydroxide / acetonitrile / 1 h / Reflux

With sulfuric acid; sodium hydride; potassium hydroxide; In 1,4-dioxane; methanol; acetonitrile; mineral oil; 2.1: |Claisen-Schmidt Condensation;

DOI:10.1080/00397911.2013.869341

Reference yield:

5-acetyl-1-methoxymethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (1402905-98-9) → 5-[3-(4-bromophenyl)-2-propenoyl]-1-ethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (1213702-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 3.5 h / 20 °C

2: sulfuric acid / 1,4-dioxane

3: potassium hydroxide / acetonitrile / 1 h / Reflux

With sulfuric acid; potassium hydroxide; In 1,4-dioxane; methanol; acetonitrile; 1: |Claisen-Schmidt Condensation;

DOI:10.1080/00397911.2013.869341

upstream raw materials:

5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

ethyl bromide

5-[3-(4-bromophenyl)-2-propenoyl]-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

5-acetyl-1-methoxymethyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Downstream raw materials:

5-[5-(4-bromophenyl)-6-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-1-ethyl-4-phenyl-3,4-dihydro-2(1H)-pyrimidone