2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

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Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid
CAS No.:1403380-80-2
Molecular Formula:C₂₇H₂₈O₅
Molecular Weight:432.516
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

There total 10 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1403381-12-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

: 1403380-80-2
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

Guidance literature:: methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate; With water; potassium hydroxide; In ethanol; for 1h; Reflux;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 114776-15-7
2-chloro-4-fluoro-5-nitrobenzoic acid

: 1403380-80-2
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 6 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

3.2: 3 h / Reflux

4.1: perchloric acid / 3 h / -20 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 75 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 4 h / 100 °C / Inert atmosphere

7.1: hydrogen / palladium on activated charcoal / methanol / 1 h / 20 °C

8.1: tert.-butylnitrite / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

9.1: potassium hydroxide; water / ethanol / 1 h / Reflux

9.2: pH 1

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; water; hydrogen; sodium carbonate; potassium carbonate; triethylamine; potassium hydroxide; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2252-51-9
2-choro-4-fluorobenzoic acid

: 1403380-80-2
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium nitrate; sulfuric acid / 4 h / 0 - 20 °C

2.1: thionyl chloride / 2 h / Reflux

3.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: 20 °C

3.3: 6 h / Reflux

4.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

4.2: 3 h / Reflux

5.1: perchloric acid / 3 h / -20 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 75 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 4 h / 100 °C / Inert atmosphere

8.1: hydrogen / palladium on activated charcoal / methanol / 1 h / 20 °C

9.1: tert.-butylnitrite / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

10.1: potassium hydroxide; water / ethanol / 1 h / Reflux

10.2: pH 1

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; sulfuric acid; water; hydrogen; sodium carbonate; potassium carbonate; potassium nitrate; triethylamine; potassium hydroxide; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;