methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

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Chemical Name:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate
CAS No.:1403381-12-3
Molecular Formula:C₂₈H₃₀O₅
Molecular Weight:446.543
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

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Technology Process of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

There total 9 articles about methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1403381-11-2
methyl 2-[5-amino-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]-2-(tert-butoxy)-acetate

: 1403381-12-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

Guidance literature:: With tert.-butylnitrite; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 114776-15-7
2-chloro-4-fluoro-5-nitrobenzoic acid

: 1403381-12-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 6 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

3.2: 3 h / Reflux

4.1: perchloric acid / 3 h / -20 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 75 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 4 h / 100 °C / Inert atmosphere

7.1: hydrogen / palladium on activated charcoal / methanol / 1 h / 20 °C

8.1: tert.-butylnitrite / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; hydrogen; sodium carbonate; potassium carbonate; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2252-51-9
2-choro-4-fluorobenzoic acid

: 1403381-12-3
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4-phenoxyphenyl]acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium nitrate; sulfuric acid / 4 h / 0 - 20 °C

2.1: thionyl chloride / 2 h / Reflux

3.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: 20 °C

3.3: 6 h / Reflux

4.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

4.2: 3 h / Reflux

5.1: perchloric acid / 3 h / -20 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 75 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 4 h / 100 °C / Inert atmosphere

8.1: hydrogen / palladium on activated charcoal / methanol / 1 h / 20 °C

9.1: tert.-butylnitrite / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; sulfuric acid; hydrogen; sodium carbonate; potassium carbonate; potassium nitrate; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;